Harnessing Ferroptosis to Combat Alzheimer’s Disease

Abstract

Millions of individuals all over the world suffer with Alzheimer’s disease (AD), a devastating neurological condition. There is currently no cure for AD, and the medications that are available only offer short-term symptom alleviation at best. So, it is crucial to find novel treatment targets for AD. In addition to apoptosis and necrosis, ferroptosis has emerged as a potential therapeutic target. Lipid peroxide buildup is a hallmark of ferroptosis, which is controlled by a web of interconnected signalling pathways. Targeting ferroptosis may offer therapeutic promise, as it has recently been implicated in the pathophysiology of AD.