An Insight into the Use of Novel Antibiotic Regimes for Post Neurosurgical Meningitis a Case Report and Review of Literature

Abstract

Central nervous system (CNS) infections are associated with high mortality rates, morbidity, limited antibiotic treatment options, and high cost of therapy especially in low and middle-income countries. Post-neurosurgical infections are often associated with multi-drug resistant organisms. Given the limited options of antibiotics due to blood-brain and blood-cerebrospinal fluid (CSF) barriers, exploring various antibiotic combinations including the latest ones is imperative. Drugs like Ceftazidime- Avibactam and Aztreonam may be useful in carbapenem-resistant gram-negative infections. More robust studies may be designed to offer better treatment options for difficult CNS infections.