Ki-67 Labeling Index and Knosp Classification of Pituitary Adenomas

Abstract

Pituitary adenomas (PAs) are common lesions that are reported to be the second most frequent primary brain tumor.The classification of pituitary tumors is frequently updated to optimize guidance for clinical treatment based on current knowledge. To date, the World Health Organization conducts periodic expert review consensus meetings and publishes the results. These include recommendations for the behavior of more aggressive, high Ki-67 index (>3%) pituitary. A high Knosp grade (>3) is also considered to exert a high risk of recurrence of pituitary tumors. We reported an inverse relationship between the Ki-67 labeling index and Knosp grade for functional pituitary adenomas and nonfunctional pituitary adenoma (Spearman correlation coefficient in functional pituitary adenomas r=-0.59, p